Search results for " conjugate"
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Tackling Analytical Method Development for ADCs
The challenge with this method, according to Kaur, is that the extinction coefficient (λmax) of the drug may change when conjugated to the antibody or in a different buffer. In addiiton, the drug and …
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ADC Development Robust Despite Lackluster Performance
Because the stable linkers conjugate cytotoxic molecules to the mAb, ADCs can remain inactive while in circulation within the patient’s body. The agent is internalized by the tumor cell after it is bo…
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Addressing the Challenges in Downstream Processing Today and Tomorrow
In the future, mAbs may represent a smaller percentage of the pipeline as portfolios concentrate more on development of antibody fragments, nanobodies, biosimilar protein therapeutics, conjugated prot…
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Single-Domain Antibodies for Brain Targeting
…ariants (diabodies, triabodies, minibodies, sdAbs) along with antibody-drug or antibody-nanoparticle conjugates are emerging as credible alternatives. Many of these products are under clinical invest…
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Witnessing Major Growth in Next-Generation Antibodies
The global market for next-generation antibodies, including antibody drug conjugates (ADCs), engineered antibodies, bispecific antibodies, antibody fragments, antibody-like proteins and biosimilar ant…
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Evolving demands of process development services
And, more recently, there has been a high demand for the CDMOs that can handle oligos, peptides, and various complex conjugates. Novel conjugates involving combinations of oligos, peptides, high poten…
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Extractables Studies for Single‑Use Systems Used in ADC Manufacturing
Single‑use (SU) systems have great potential in antibody‑drug conjugates (ADC) manufacturing. The use of organic solvents in the ADC process might , however, raise questions about potential leac…
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Being Thorough When Transferring Technology
BioPharm: Are there specific challenges for the tech transfer of antibody-drug conjugates (ADCs)? Monoclonal antibodies? Cell therapies?
Moscariello and Young (CMC Biologics): The major challenges…
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SEC in the Modern Downstream Purification Process
…phic modes that are driven by chemical interactions between the sample being purified and the ligand conjugated to the stationary phase.
New applications for SEC
SEC has experienced a bit of …
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Genetic Vaccine Platforms Demonstrate Their Potential
Recombinant vaccines include subunit, virus-like particle (VLP), conjugate, and viral-vectored vaccines. Genetic vaccines include messenger RNA (mRNA)/DNA. Alternatively, vaccines can be classified in…